Table 1.
Main Characteristics of Studies Included for the Association between the XPG Asp1104His, XRCC2 Rs3218536 A/G and RAD51 135G/C Polymorphisms and Colorectal Cancer
| Study | Year | Country | Ethnicity | Source of controls | Genotype methods | Genotype (case/control) | Allele (case/control) | PHWE | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Asp/Asp | Asp/His | His/His | Asp | His | |||||||
| Sun et al. | 2015 | China | Asian | HB | PCR–RFLP | 890/910 | 216/227 | 476/497 | 198/186 | 908/951 | 872/869 | 0.004 |
| Kabzinski, J., et al. | 2015 | Poland | Caucasian | HB | QPCR | 234/238 | 36/43 | 171/175 | 27/20 | 243/261 | 225/215 | 0.001 |
| Paszkowska-Szczur, K., et al. | 2015 | Poland | Caucasian | PB | MassARRAY | 733/1358 | 429/869 | 272/404 | 32/85 | 1130/2142 | 336/576 | 0.001 |
| Steck, S. E, et al. | 2014 | USA | African | PB | MassARRAY | 224/317 | 65/100 | 120/151 | 39/66 | 250/351 | 198/283 | 0.519 |
| Steck, S. E., et al. | 2014 | USA | Caucasian | PB | MassARRAY | 298/532 | 183/335 | 100/170 | 15/27 | 466/840 | 130/224 | 0.372 |
| Du, H., et al. | 2014 | China | Asian | HB | Taqman Assay | 878/884 | 286/355 | 459/405 | 133/124 | 1031/1115 | 725/653 | 0.622 |
| Liu, D., et al. | 2012 | China | Asian | PB | PCR–RFLP | 1028/1085 | 233/329 | 603/537 | 192/219 | 1069/1195 | 987/975 | 0.996 |
| Gil, J., et al. | 2012 | Poland | Caucasian | PB | PCR–RFLP | 132/100 | 86/64 | 35/31 | 11-May | 207/159 | 57/41 | 0.624 |
| Canbay, E., et al. | 2011 | Turkey | Caucasian | HB | PCR–RFLP | 79/247 | 43/148 | 34/83 | Feb-16 | 120/379 | 38/115 | 0.351 |
| Joshi, A. D., et al | 2009 | USA | Caucasian | FB | Taqman assays | 308/361 | 183/213 | 114/137 | 11-Nov | 480/563 | 136/159 | 0.046 |
| Pardini, B., et al | 2008 | Czech | Caucasian | HB | PCR–RFLP | 532/532 | 334/356 | 177/153 | 21/23 | 845/865 | 219/199 | 0.211 |
| Huang, W. Y., et al. | 2006 | USA | Caucasian | PB | Sequencing | 679/697 | 407/403 | 243/265 | 29/29 | 1057/1071 | 301/323 | 0.073 |
| Bigler, J., et al. | 2005 | USA | Caucasian | PB | Taqman assays | 713/616 | 440/353 | 237/226 | 36/37 | 1117/932 | 309/300 | 0.917 |
| Mort, R., et al. | 2003 | UK | Caucasian | HB | PCR-RFLP | 40/33 | - | - | - | 67/58 | 13/22 | - |
| XRCC2 rs3218536 A/G | Year | Country | Ethnicity | Source | Genotype methods | Total | A/A | G/A | G/G | A | G | PHWE |
| Cetinkunar, S., et al. | 2015 | Turkey | Caucasian | HB | PCR-RFLP | 71/86 | 09-Nov | 30/21 | 32/54 | 48/43 | 94/129 | 0.001 |
| Krupa, R., et al. | 2011 | Poland | Caucasian | HB | PCR-RFLP | 100/100 | 75/84 | 18/14 | 07-Feb | 168/182 | 32/18 | 0.146 |
| Curtin, K., et al. | 2009 | UK & US | Caucasian | PB | Sequencing | 1227/1380 | 1014/1167 | 185/204 | 10-Sep | 2213/2538 | 205/222 | 0.979 |
| Moreno [16] | 2006 | Spain | Caucasian | HB | APEX | 350/316 | 287/265 | 57/45 | 06-Jun | 631/575 | 69/57 | 0.018 |
| Tranah, G. J., et al. | 2004 | USA | Caucasian | PB | TaqMan | 518/522 | 450/441 | A/G+G/G | - | - | - | - |
| Tranah, G. J., et al. | 2004 | USA | Caucasian | PB | TaqMan | 354/688 | 302/582 | A/G+G/G | - | - | - | - |
| RAD51 135 G/C | Year | Country | Ethnicity | Source | Genotyping | Total | G/G | G/C | C/C | G | C | PHWE |
| Cetinkunar, S., et al. | 2015 | Turkey | Caucasian | HB | PCR-RFLP | 71/86 | 39/21 | 21-Nov | Nov-54 | 99/53 | 43/119 | 0.001 |
| Nissar, S., et al. | 2014 | India | Asian | HB | PCR-RFLP | 100/120 | 25/60 | 56/25 | 19/35 | 106/145 | 94/95 | 0.001 |
| Gil, J., et al. | 2012 | Poland | Caucasian | HB | PCR-RFLP | 133/100 | 100/73 | 29/27 | 4/0 | 229/173 | 37/54 | 0.118 |
| Mucha, B., et al. | 2012 | Poland | Caucasian | PB | PCR-RFLP | 200/200 | 161/157 | 34/37 | 05-Jun | 356/351 | 44/49 | 0.048 |
| Romanowicz-Makowska, H., et al. | 2012 | Poland | Caucasian | HB | PCR-RFLP | 320/320 | 51/91 | 56/164 | 213/65 | 158/346 | 482/294 | 0.569 |
| Krupa, R., et al. | 2011 | Poland | Caucasian | HB | PCR-RFLP | 100/100 | 61/36 | 36/35 | Mar-29 | 158/107 | 42/93 | 0.003 |
HWE, Hardy-Weinberg equilibrium; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism;. PB, population-based; HB: hospital-based; FB, Family-based; NHS, Nurses’ Health Study; HPFS, Health Professionals Follow-up Study; APEX, arrayed primer extension