Table 1.

Selected nucleotide pattern frequencies for the human data

	GRCh37	GRCh38
1	aa, aaa, ac, aca, acg	aa, aaa, ac, aca, act
2	act, ag, aga, at, ata	ag, aga, at, ata, atc
3	atc, atg, att, ca, caa	atg, att, ca, caa, cac
4	cac, cag, cat, cc, cca	cag, cat, cc, cca, ccc
5	ccc, cg, cgc, ct, cta	cg, cgc, ct, cta, ctc
6	ctc, ctg, ga, gac, gag	ctg, ga, gac, gag, gc
7	gc, gcg, gg, ggg, gt	gcg, gg, ggg, gt, gta
8	gtc, gtg, ta, tac, tag	gtc, gtg, ta, tac, tag
9	tat, tc, tca, tct, tg	tat, tc, tca, tct, tg
10	tga, tgt, tt, ttg, ttt	tga, tgt, tt, ttg, ttt

GRCh37 and GRCh38 data sets were analyzed to identify 50 pattern frequencies with the highest PCA loadings. The patterns “acg” and “gta”, in bold, are the only difference. In the additional files, we listed these nucleotide pattern frequencies, ordered by PCA loadings