Table 3.

Summary of main results of primary and secondary outcomes

					Heterogeneity
Outcome analyzed	Studies	Patients	OR or SMD (95% CI)	p Value	I 2 Statistic	p Value
Mortality overall	6	1728	OR 0.64 (0.37, 1.11)	0.11	42%	0.12
Mortality in low LVEF	5	1224	OR 0.51 (0.32, 0.82)	0.005	0%	0.66
Need for RRT overall	6	1728	OR 0.63 (0.42, 0.94)	0.02	0%	0.91
Need for RRT in low LVEF	5	1224	OR 0.55 (0.31, 0.97)	0.04	0%	0.90
AF and SVT overall	5	1695	OR 0.62 (0.32, 1.18)	0.15	79%	0.0007
AF and SVT in low LVEF	4	1141	OR 0.52 (0.19, 1.40)	0.20	84%	0.0003
Myocardial damage overall	4	1645	OR 0.89 (0.52, 1.53)	0.68	29%	0.24
Myocardial damage in low LVEF	3	1141	OR 0.60 (0.15, 2.41)	0.47	53%	0.12
Mechanical support overall	6	1728	OR 0.38 (0.13, 1.10)	0.07	82%	<0.0001
Mechanical support in low LVEF	5	1224	OR 0.29 (0.09, 1.00)	0.05	85%	<0.0001
Hypotension overall	5	1695	OR 1.41 (0.92, 2.18)	0.12	0%	0.54
Hypotension in low LVEF	4	1191	OR 1.31 (0.82, 2.08)	0.26	0%	0.52
LCOS in low LVEF	4	1191	OR 0.55 (0.38, 0.79)	0.001	9%	0.35
AKI (risk, injury, failure of RIFLE criteria)	3	817	OR 0.64 (0.44, 0.94)	0.02	9%	0.33
Duration of MV overall	3	567	SMD −0.11 (−0.28, 0.05)	0.18	0%	0.61
ICU LOS overall	4	1419	SMD −0.41 (−0.83, 0.02)	0.06	89%	<0.0001
ICU LOS in low LVEF	3	962	SMD −0.78 (−1.90, 0.34)	0.17	92%	<0.0001
Hospital LOS overall	3	567	SMD −0.73 (−1.89, 0.43)	0.22	93%	<0.0001

Abbreviations: AF Atrial fibrillation, AKI Acute kidney injury, ICU Intensive care unit, LCOS Low cardiac output syndrome, LOS Length of stay, LVEF Left ventricular ejection fraction, MV Mechanical ventilation, PICOS Population, intervention, comparison, outcomes, and study design, RIFLE Risk, injury, failure; loss, end-stage renal disease, RRT Renal replacement therapy, SMD Standard mean difference, SVT Supraventricular tachycardia

Results are presented as OR or SMD, as appropriate, with 95% CI. Results presented in bold are statistically significant or with a trend toward statistically significant result