Baseline parameters were recorded continuously over 28 hr in a 12hr-light/12hr-dark (shaded area) cycle. Data lines for littermate (black, n = 10), K14cre-HIF-1α (blue, n = 9), K14cre-HIF-2α (red, n = 7), K14cre-Arg1 (red, n = 5), K14cre-NOS2 (orange, n = 6) (A) show heart rate as mean beads per minute (B) mean blood pressure shown as mm/Hg, (C) temperature shown as mean degree’s Celsius and (D) physical activity shown as mean meters per hour. Statistical analysis: Area under curved was determined for each mouse per group and each group was further analysed by mann-Whitney test. Mean blood pressure K14cre-HIF-2α (p=0.0274) and K14cre-NOS2 (p=0.0120) and skin temperature K14cre-Arg1 (p=0.0350) compared to littermate control.