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. 2017 Oct 19;6:e28755. doi: 10.7554/eLife.28755

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© 2017, Cowburn et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 8. — (A and B) Ventilation rate in response to acute hypoxia was determined by whole-body plethysmography. Resting/normoxia ventilation was determined 60 min before acute hypoxic stimulus. Data shown as mean breaths/minute (HIF-1α n = 6, HIF-2α n = 4) (C) Percentage arterial oxygen saturation was recorded during the acute hypoxic challenge. Data recorded at 5 s interval mean (HIF-1α n = 6, HIF-2α n = 4). Keratinocyte HIF-2α deletion does not influence carotid body development. Quantification of (D) carotid body volume, (E) CB TH⁺ cells (F) CB TH⁺ cells per area tissue, (G) representative photomicrographs of TH⁺ cells in the carotid bifurcation in littermates and K14cre-HIF-2α mice.