Table 1.

Particle size, zeta potential, encapsulation efficiency, drug loading and β-sheet content of SF, SFNPs, TPL-SFNPs, CL-SFNPs (n=3)

Sample	Particle size (nm ± s.d)	Zeta Potential (mV ± s.d)	EE (% ± s.d)	DL (μg/mg ± s.d)	β-sheet content
SF	-	-	-	-	16.8
SFNPs	201.0 ± 5.1	−21.1 ± 3.3	-	-	35.3
TPL-SFNPs	166.4 ± 4.6	−27.2 ± 2.0	81.8 ± 2.8	57.7 ± 4.7	57.7
CL-SFNPs	170.4 ± 2.3	−25.5 ± 2.6	87.0 ± 1.1	63.5 ± 3.8	77.6

Novel combination of triptolide and celastrol loaded silk fibroin nanoparticles show synergistic anti-pancreatic cancer effect in vitro