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The Mean First Passage Time (MFPT) in a logarithmic scale, as a function of the milestone number. The blue line shows the MFPT of the native protein. The red line is for a mutant protein in which lysine residues 66, 71, and 220 are mutated to arginine residues. The overall mean first passage for the native protein was 33.5ms and 56ms for the arginine mutant, which corresponds closely to the measured PPi release rate of 27 s-1 with an RNA template.6
