TABLE 3.
Culture yield of patients with a confirmed PJI prior to surgerya
| Study authors | Reference test | Prophylaxis | Patients with acute and chronic infections |
Patients with chronic infections only |
||||
|---|---|---|---|---|---|---|---|---|
| No. of patients with culture yield/total no. (%) | 95% CI | P value | No. of patients with culture yield/total no. (%) | 95% CI | P value | |||
| Bedenčič et al. (22)b | Intraoperative samples before prophylaxis | Yes | 19/24 (79) | 58–93 | 19/24 (79) | 58–93 | ||
| No | ||||||||
| Tetreault et al. (21) | Control group without prophylaxis | Yes | 29/34 (85) | 73–98 | 0.43 | 13/16 (81) | 60–100 | 1.00 |
| No | 29/31 (94) | 84–100 | 14/16 (88) | 70–100 | ||||
| Burnett et al. (19) | Preoperative synovial fluid | Yes | 26/26 (100) | NA | 19/19 (100) | NA | ||
| No | ||||||||
| Ghanem et al. (23) | Control group without prophylaxis | Yes | 63/72 (88) | 80–95 | 0.44 | 27/30 (90) | 79–100 | 1.00 |
| No | 91/99 (92) | 86–98 | 38/41 (93) | 84–100 | ||||
| Al-Mayahi et al. (3) | Control group without prophylaxis | Yes | 8/9 (89) | 63–100 | 0.29 | ND | ||
| No | 224/232 (97) | 95–99 | ND | |||||
| Pooled (all studies) | Yes | 145/165 (88) | 83–93 | 0.004 | 78/89 (88) | 80–99 | 0.59 | |
| No | 344/362 (95) | 93–97 | 52/57 (91) | 83–99 | ||||
a
Summary of the culture yield of patients with a diagnosed prosthetic joint infection (PJI) prior to surgery who underwent revision surgery with or without preoperative antimicrobial prophylaxis (3, 19, 21–23). Data are given for the total patients in the group as well as for the subanalysis of the patients with solely chronic infections. NA, not applicable; ND, no data.
b
From the data for this cohort, only 24 out of 40 patients with a positive culture before the administration of antimicrobial prophylaxis were analyzed in order to calculate the sensitivity of cultures after antimicrobial prophylaxis.