Table 1.
Parameter | Renal function group | ||||
---|---|---|---|---|---|
Normal | Mild | Moderate | Severe | ESRD | |
Subjects (n) | 14 | 11 | 11 | 10 | 10 |
Sex [M/F (n)] | 9/5 | 6/5 | 6/5 | 6/4 | 7/3 |
Age (years) | 54.6 ± 9.1 | 62.9 ± 8.0 | 66.5 ± 6.6 | 62.8 ± 9.1 | 48.2 ± 7.2 |
Weight (kg) | 84.9 ± 19.1 | 80.1 ± 13.8 | 78.7 ± 16.5 | 78.1 ± 22.7 | 97.2 ± 15.7 |
BMI (kg/m2) | 29.2 ± 4.1 | 28.5 ± 4.3 | 27.9 ± 5.2 | 27.8 ± 5.2 | 31.7 ± 5.1 |
FPG (mmol/L) | 5.6 ± 0.5 | 5.8 ± 0.6 | 6.6 ± 1.8 | 5.8 ± 1.6 | 5.2 ± 2.4 |
T2D (n) | 0 | 1 | 2 | 2 | 4 |
Estimated CLCR a (mL/min) | 119.7 ± 42.6 | 63.2 ± 9.0 | 41.5 ± 5.7 | 21.5 ± 6.2 | 15.4 ± 6.2 |
All data are mean ± standard deviation unless stated otherwise
BMI body mass index, CL CR creatinine clearance, ESRD end-stage renal disease, F female, FPG fasting plasma glucose, M male, T2D type 2 diabetes mellitus
aCLCR was calculated using the Cockcroft–Gault formula