Table 2.
Photoactivity of ZnPc and ZnPc–TiO2 on Leishmania promastigotes and different mammalian cell lines
| Fluency (J/cm2) | IC50 (μM) | CC50 (μM) | |||||
|---|---|---|---|---|---|---|---|
| Leishmania parasites | Mammalian cell lines | ||||||
| Chagasi | Panamensis | HDFs | THP-1 | HepG2 | Vero | ||
| ZnPc | 0 | >15 | 14.76 | 9.21 | 7.74 | 10.70 | 0.78 |
| 2.5a | 12.86 | 6.63 | 1.08 | 0.14 | 0.28 | 0.24 | |
| 2.5b | 0.19 | 0.39 | 0.15 | 0.02 | 0.035 | 0.09 | |
| 10a | 5.63 | 5.63 | 0.05 | 0.17 | 0.086 | 0.038 | |
| ZnPc–TiO2 | 0 | > 10 | > 10 | > 10 | > 10 | > 10 | 0.087 |
| 2.5a | > 10 | > 10 | 5.51 | 7.45 | > 10 | 0.079 | |
| 2.5b | > 10 | > 10 | 3.54 | 0.28 | 0.43 | 0.023 | |
| 10a | > 10 | > 10 | nd | 2.00 | 5.50 | 0.001 | |
ZnPc zinc phthalocyanine, IC 50 concentration that induces 50% of parasite inhibition, CC 50 cytotoxic concentration that induces 50% of cell death, HDFs human-derived fibroblasts, THP-1 human macrophages, HepG2 human heptocellular carcinoma cells, nd not disclosed
aLaser light irradiation (670 nm)
bBiological photoreactor irradiation (597–752 nm)