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. 2017 Mar 13;56(11):1355–1368. doi: 10.1007/s40262-017-0526-4

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Geometric mean of dose-normalised ixazomib concentrations observed in: a TOURMALINE-MM1 binned by visit number (open black circles) with individual observations (grey dots) at the actual sampling times. Triangles indicate protocol-specified dose times and numbers indicate the number of PK samples included in each geometric mean calculation. b Cycle 1 in studies with 21-day treatment cycles (TW dosing) binned by protocol-specified sampling time. Triangles indicate protocol-specified dose times. Error bars show 95% CI of the geometric mean. c Cycle 1 in studies with 28-day treatment cycles (W dosing), binned by protocol-specified sampling time. Triangles indicate protocol-specified dose times. Error bars show 95% CI of the geometric mean. CI confidence interval, IV intravenous, PK pharmacokinetic, PO oral, TW twice weekly, W weekly