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Structural model describing the pharmacokinetics of ixazomib. ALAG1 absorption lag time, CL clearance, F absolute bioavailability of an oral ixazomib dose, IV intravenous, KA absorption rate constant, Q 3 first inter-compartmental clearance, Q 4 second inter-compartmental clearance, V 2 central volume of distribution; V 3 volume of distribution of first peripheral compartment, V 4 volume of distribution of second peripheral compartment
