Table 1.
Demographics, clinical characteristics and outcomes of patients who presented with CR-KP NSSTI.
| NU-CRE101 | NU-CRE176 | NU-CRE212 | NU-CRE265 | |
|---|---|---|---|---|
| Clinical Characteristics | ||||
| Age, Sex | 69, M | 50, F | 46, M | 43, M |
| Charlson Score | 6 | 4 | 6 | 6 |
| Specific Comorbidities | Bladder cancer on chemotherapy | Myasthenia gravis on chronic corticosteroids | DM, CKD on dialysis, failed kidney and pancreas transplant on IS | DM, CKD on dialysis |
| Immunosuppresed | Yes | Yes | Yes | No |
| Community-acquired infection | No | Yes | No | No |
| Post-surgical Infection | No | No | Yes | Yes |
| Modified SOFA score | 2 | 4 | 7 | 4 |
| Fever/Hypotension | Yes/No | No/Yes | Yes/Yes | No/No |
| Microbiologic characteristics | ||||
| Culture source | Tissue | Tissue/Blood | Tissue | Tissue |
| Polymicrobial culture | VRE | No | MSSA | No |
| Meropenem Susceptibility | R (>16) | R (>16) | R (>16) | R (>16) |
| Management | ||||
| Source control achieved (surgery) | Yes | Yes | Yes | Yes |
| Time to effective antibiotic (hs) | 39.8 | 80.7 | 70.8 | 131.1 |
| Duration of effective antibiotic (days) | 19 | unknowna | 28 | unknownb |
| Outcomes | ||||
| Length of hospital stay (days) | 23 | 6 (transferred) | 13 | 55 |
| In-hospital death | survived | survived | survived | survived |
| Relapse | No | after 5 months | after 4 months | No |
| Overall death (post-discharge) | Yes | Yes | No | No |
| Death attributable to infection | No | Yes | No | No |
DM, diabetes mellitus; CKD, chronic kidney disease; IS, Immunos supressants; VRE, vancomycin-resistant Enterococcus spp.; MSSA, methicillin-susceptible Staphylococcus aureus.
aTotal duration of effective antibiotic treatment is unknown, because the patient was transferred to another facility after 6 days of treatment.
bTotal duration of effective antibiotic treatment is unknown, because the patient was transferred to a rehabilitation facility and had no follow up at our institution.