Table 2.
Baseline echocardiographic data of AAV treated mdx:utr −/− mice
WT | mdx:utr −/− Saline | mdx:utr −/− AAV9.shSLN | |
---|---|---|---|
IVSd (mm) | 0.90 ± 0.04 | 0.95 ± 0.14 | 0.78 ± 0.08 |
IVSs (mm) | 1.31 ± 0.04 | 0.98 ± 0.08* | 1.3 ± 0.08 |
LVIDd (mm) | 4.06 ± 0.11 | 3.1 ± 0.24$ | 3.12 ± 0.1$ |
LVIDs (mm) | 2.58 ± 0.07 | 2.43 ± 0.20 | 1.89 ± 0.09# |
LVPWd (mm) | 0.77 ± 0.08 | 0.72 ± 0.06 | 0.9 ± 0.09 |
LVPWs (mm) | 1.12 ± 0.06 | 0.89 ± 0.05* | 1.02 ± 0.09 |
FS (%) | 37 ± 0.6 | 22 ± 1.0** | 40 ± 1.4 |
EF (%) | 73 ± 2.3 | 44 ± 1.8** | 71 ± 1.8 |
HR (bpm) | 449 ± 27 | 585 ± 7$ | 559 ± 58 |
IVSd interventricular septal end diastole, IVSs interventricular septal end systole, LVIDd left ventricular internal diameter end diastole, LVIDs left ventricular internal diameter end systole, LVPWd left ventricular posterior wall end diastole, LVPWs left ventricular posterior wall end systole, FS fractional shortening, EF ejection fraction, HR heart rate.
$ p < 0.05 vs. WT; * p < 0.05 vs. other groups; **p < 0.005 vs. other groups; # p < 0.06 vs. other groups. n = 4 per group. Data are presented as mean ± SEM