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. 2017 Oct 19;8:1041. doi: 10.1038/s41467-017-01144-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Effects of deleting C-zone repeats on A-band width. a Left, example of SIM images obtained using cardiac and skeletal muscle sections labeled with I103 titin antibody (A-band, red) and α-actinin (Z-disk, green). Right, summarized results of the A-band width measurements. In both muscle types the offsets of the linear regression lines are significantly lower in Ttn ^ΔC1-2 mice. b, c Left, representative IEM images of sarcomeres labeled with cMyBP-C (b) or A77/8 (c) with density profiles shown at bottom. Obtained summarized results are shown to the right. c The distance between A77/8 epitopes was measured and used to determine A-band shrinkage in skeletal muscle. Right, Shrinkage-corrected A-band width results. All linear regression fits show positive slopes but none are significantly different from zero. Line offsets are significantly reduced in Ttn ^ΔC1-2 mice. Statistical analysis is provided in Supplementary Table 4 (**** denotes p < 0.0001). Scale bars, 1 μm. The 8-week-old male mice were used (SIM: 10 WT and 9 Ttn ^ΔC1-2, IEM: 4 WT and 4 Ttn ^ΔC1-2)