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. 2017 Oct 19;8:1041. doi: 10.1038/s41467-017-01144-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Effect of reduced thick filament length on slack sarcomere length (a), slack cell length (b), and passive tension (c). Skinned myocytes (a, left) and skinned papillary muscle (a, right) isolated from the left ventricle have shorter slack sarcomere length in Ttn ^ΔC1-2 mice, but cell length is longer (b). c Passive tension of skinned cardiac myocytes as a function of sarcomere length increases steeper in Ttn ^ΔC1-2 mice. Individual data points were fit with a fourth-order polynomial function. Dashed red line represents the fit of the Ttn ^ΔC1-2 data right-shifted by 173 nm. Note that the right-shifted Ttn ^ΔC1-2 fit overlaps well with WT data. a, left: mean results from 5 hearts (20 cells per heart); a, right: mean results from 12 muscles from 12 mice; c mean results from 5 myocytes from 3 hearts. Female mice at 48–56 days of age were used (n = 6 WT and n = 6 Ttn ^ΔC1-2). Error bars are s.e.m. Statistical analysis with a two-tailed t-test. Additional statistical analysis is provided in Supplementary Table 4 (** denotes p < 0.01, ***p < 0.001, and ****p < 0.0001)