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. 2017 Oct 19;7:13534. doi: 10.1038/s41598-017-13903-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representation of Large component networks inferred from (a) control and (b) tumour data. Hiveplot representation of the networks inferred from (c) control, and (d) tumour data. Yellow-green nodes represent miRs, meanwhile turquoise nodes represent mRNAs. For (a) and (b) node size is proportional to node degree. For (c) and (d) hiveplot visualization: network nodes are represented in the axes ordered by increasing degree from its centre; edges between yellow-green axes represent miR-miR edges; between turquoise axes the mRNA-mRNA edges; and between yellow-green and turquoise axes the miR-mRNA ones. Effect on component disintegration after mRNA removal from the largest component of the networks inferred from (e) control and (f) tumour data.