Table 2.

Relevant miRs obtained by network analysis and their involvement in cancer. This table shows miRs first neighbours of miR-200 or miR-199, and miRs in DLK1-DIO3 cluster.

miR	Involvement in cancer	Expression		Reference
	miR-200 tumour network	−5p	−3p
miR-381	Indirect supressor of migration,		−1.49	83
	associated to self-renewal			84
miR-379	Underexpressed in breast cancer,	−1.19	−1.40	85
	cyclin B1 was identified as target
miR-100	Supression of breast cancer cells migration	−1.69		86
	though inhibition of Wnt/beta-catenin pathway
	EMT activator, tumorigenesis and invasion inhibitor			86
miR-96	Strongly upregulated in breast cancer, important for	3.16		87
	cell growth and migration
miR-199 tumour network		5-p	3-p
miR-145	Inhibit growth and migration of breast cancer cells	−2.27	−1.52	88
miR-656	Downregulated in multiple human cancers,		−1.29	89
	lining it with tumour suppression
miR-655	Linked to MET inhibition in breast cancer, upregulation is		−1.01	90
	linked to inhibition of migration and invasion
miR-493	Reduced survival of breast cancer patients with aggressive			91
	tumours and microtubule drugs resistance	1.35	1.49
DLK1-DIO3 cluster		5-p	3-p
miR-379	Related to EMT and EMT in a prostate cancer model	−1.19	−1.40	92
miR-495	Linked to repression of the signalling between TWIST-1, SMI-1, ZEB-1/2		−1.50	52
	and miR-200