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. 2017 Oct 19;7:13556. doi: 10.1038/s41598-017-13786-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AAV-tau injection induces behavioral deficits: the effects of the P301S and 2P modifications. (a) Open field test performed at 3 and 7 months after AAV-tau injection, compared to the control group injected with AAV-maxFP. Data represent the distance travelled by each mouse on average, for each experimental group. (b) Rotarod test performed at 1.5 and 7 months after AAV-tau injection, compared to the control group injected with AAV-maxFP. The graph shows the average time on the rotating rod for each experimental group. AAV-maxFP: n = 15 mice; AAV-WT: n = 12; AAV-P301S: n = 13. Statistical analysis: two-way ANOVA (time × group) with repeated measures, followed by Newman-Keuls post-hoc test. Open field: group effect F(2,37) = 4.29; Rotarod: group × time effect F(2,37) = 4.38, *p < 0.05; **p < 0.01; ***p < 0.001. (c) Rotarod test to compare AAV-maxFP, AAV-WT and AAV-2P at 1.5, 3 and 7 months after vector injection. The graph shows the average time on the rotating rod for each experimental group. AAV-maxFP: n = 4 mice; AAV-WT: n = 16; AAV-P301S: n = 13. Statistical analysis: two-way ANOVA (time × group) with repeated measures, followed by Fisher’s LSD post-hoc test. Group effect F(2, 30) = 4.18, *p < 0.05.