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. 2017 Oct 19;7:13530. doi: 10.1038/s41598-017-13626-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The hypothetical brain circuitry of sad emotion influencing attentional control in facial expression processing in MDD patients. From dynamic perspective which begins from 200 ms (initial attentional control) to 300 ms (sustained attentional control), MDD patients exhibit a sad-related developing procedure, changing from inferior temporal gyrus (ITG) to bilateral ventral prefrontal (AVPFC), which is quite different with HC. MDD patients show abnormal changes in attentional control ability compared with healthy controls in this periods. MDD: Major Depressive Disorder; HC: Healthy Control.