Table 1.
Effects of pharmacological interventions on metabolic parameters.
| Control | DM | DMI | DMS | DMIS | CS | |
|---|---|---|---|---|---|---|
| Body weight (g) | 396.67 ± 17.21 | 245 ± 14.50* | 302.5 ± 17.69*†# | 219 ± 6.11* | 344.17 ± 14.17*†‡# | 400 ± 12.18†‡# |
| Fasting blood glucose (mg/dl) | 154.85 ± 13.93 | 565.57 ± 37.03* | 467.04 ± 40.30*† | 422.94 ± 31.92*† | 254.92 ± 32.82*†‡# | 131.08 ± 5.45†‡# |
| Plasma insulin (U/ml) | 2.47 ± 0.43 | 0.57 ± 0.24* | 0.85 ± 0.19* | 0.65 ± 0.20* | 2.20 ± 0.71†‡# | 3.23 ± 0.48†‡# |
| Plasma cholesterol (mg/dl) | 74.71 ± 3.99 | 102.92 ± 5.97* | 91.88 ± 1.55* | 95.01 ± 4.89* | 81.13 ± 1.67†# | 70.87 ± 4.62†‡# |
| Plasma triglyceride (mg/dl) | 75.27 ± 6.98 | 166.65 ± 28.62* | 163.18 ± 16.23* | 154.62 ± 26.57* | 122.22 ± 12.35 | 78.51 ± 8.09†‡# |
| Urine glucose (mg/dl) | 115.84 ± 5.84 | 8834.1 ± 375.5* | 6350.6 ± 831.9*† | 6136.9 ± 802.7*† | 6056.9 ± 426.5*† | 110.41 ± 3.08†‡# |
| Urine volume (ml/24 h.) | 18.83 ± 0.83 | 216.33 ± 14.70* | 133.67 ± 15.75*†# | 251.67 ± 6.60*† | 135.50 ± 8.43*†# | 18.67 ± 1.61†‡# |
Data presented are means ± SEM. n = 6 rats per group. C - control group; DM - diabetic group; DMI - diabetic plus insulin group; DMS - diabetic plus atorvastatin group; DMIS - diabetic and insulin plus atorvastatin group; CS - control plus atorvastatin group. *p < 0.05 vs. control and control plus atorvastatin groups, †p < 0.05 vs diabetic group, ‡p < 0.05 vs. diabetic plus insulin group, #p < 0.05 vs. diabetic plus atorvastatin group.