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. 2017 Oct 19;8:1049. doi: 10.1038/s41467-017-01119-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Chemical probes of HIV-1 Env function. a A panel of chemical probes was developed and tested for inhibition of a diverse set of HIV-1 strains from different clades. The average IC₅₀ values were calculated from those obtained in two or three independent experiments. The IC₅₀ of each compound for each virus strain is plotted on a heat map; the compounds are ordered according to the geometric mean IC₅₀ of each compound against the panel of viruses and the viruses are clustered according to the combination of IC₅₀s of the set of compounds against a specific strain. Transmitted/founder, acute/early, and primary isolates are shown with purple, light blue, and black letters, respectively. Under the conditions tested, variation of up to two orders of magnitude in sensitivity to the different compounds was observed across different HIV-1 isolates. b The geometric mean IC₅₀ of all compounds against each specified HIV-1 strain. c The geometric mean IC₅₀ of each specified compound against the panel of viruses