FIG 2.

Bacterial population doubling in an experimental model of impetigo. Pairs of human skin grafts on doubly engrafted hu-skin-SCID mice (n = 5 animals per group) were infected with either Alab49WT (●; mean average inoculum, 2,266 ± 321 CFU) and Alab49ΔfbaA (■; inoculum, 2,109 ± 628 CFU) or the ΔfbaAΔpam (▲; inoculum, 1,258 ± 160 CFU) and Δmga (▼; inoculum 1,255 ± 422 CFU) mutants. Paired t test (two-tailed) values for differences in bacterial population doubling are shown as follows: *, t ≤ 0.05; and **, t < 0.01. Differences in inoculum doses were not statistically significant between graft inoculum pairs (paired t test) (data not shown).