TABLE 1.

Distribution of fbaA among genotype-defined subpopulations of GAS

Clustera	emm pattern group	No. of isolates	No. of fbaA- positive isolatesb	No. of fbaA-negative isolates	% fbaA-positive isolatese	Comparator group	P valuec
I and II combined	All	85d	73	12	85.9
I	All	41	31	10	75.6	Cluster II, all	0.012
II	All	44	42	2	95.5
I	A-C	10	2	8	20.0	Cluster I, pattern D	<0.0001
	D	29	28	1	96.6
	E	2	1	1	NA
II	A-C	3	1	2	NA
	D	3	3	0	NA
	E	38	38	0	100
I and II combined	A-C	17	4	13	23.5	Cluster I/II, pattern D	<0.0001
	D	33	32	1	97.0	Cluster I/II, pattern E	NS
	E	43	42	1	97.7	Cluster I/II, pattern A-C	<0.0001

^aAssignment is based on accessory gene haplotypes, as described previously (13).

^bDetermined by PCR amplification of genomic DNA.

^cBy Fisher's exact test (two-tailed). NS, not significant.

^dAll 85 GAS isolates harbor distinct emm types.

^eNA, not applicable.