FIG 7.

(A to C) Effect of chronic-plus-binge alcohol administration on changes in Sca-1 (A), C/EBPβ (B), and C/EBPα (C) gene expression by bone marrow lineage-negative cells 24 h following bacteremia. The data are presented as means and SEM; n = 3 to 5. Control, i.p. saline to mice on control diet; Alcohol, acute alcohol intoxication to mice on chronic alcohol diet; Saline, i.v. saline; E. coli, 5 × 10⁷ CFU E. coli/mouse i.v. (D and E) Effect of chronic-plus-binge alcohol administration on changes in bone marrow Gr1^lo Sca-1⁺ (D) and Gr1^hi Sca-1⁺ (E) cell populations in mice challenged i.v. with saline or E. coli for 24 h. Control, i.p. saline to mice on control diet; Alcohol, acute alcohol intoxication to mice on chronic alcohol diet; Saline, i.v. saline; E. coli 1 × 10⁶, 1 × 10⁶ CFU E. coli/mouse i.v.; 5 × 10⁷ E. coli, 5 × 10⁷ CFU E. coli/mouse i.v. The data are presented as means and SEM; n = 5. Bars with different letters in each panel are statistically significantly different (P < 0.05).