FIG 1.

Mice lacking IFN-γR signaling within the hematopoietic compartment display intermediate susceptibility to ECM. WT, IFN-γR^−/−, and VAV-Cre⁺ IFN-γR2^flox/flox mice were infected intravenously (i.v.) with 10⁴ P. berghei ANKA-parasitized red blood cells (pRBCs). (A, B) The course of infection was monitored by assessing peripheral parasite levels (A) and the maximum ECM score (B) observed during the course of the experiment. Results are the combined mean values ± standard errors of the means (SEM) for the groups from six independent experiments, with 3 to 7 mice per group per experiment. (C) Percentage of mice of each strain within all experiments that developed late-stage ECM (score of ≥4) during the course of infection. Total numbers of mice used in experiments were as follows: WT, n = 43; VAV-Cre⁺ IFN-γR2^flox/flox, n = 32; IFN-γR^−/−, n = 39. (D) Survival of the different strains. Results are representative of 2 independent experiments with 4 or 5 mice per group. *, P < 0.05 between defined groups. Statistical significance was tested using Kruskal-Wallis test with Tukey's post hoc test.