FIG 5.

IFN-γR signaling within Nestin-expressing cells is redundant for ECM development. WT and Nestin-Cre⁺ IFN-γR2^flox/flox mice were infected i.v. with 10⁴ P. berghei ANKA pRBCs. (A, B) The course of infection was monitored by assessing peripheral parasite levels (A) and the maximum ECM score observed during the course of the experiment (B). Results are the combined mean values ± SEM of the groups from three independent experiments, with 3 to 10 mice per group. (C) Percentage of mice of each strain within all experiments that developed late-stage ECM (score of ≥4) during the course of infection. Total numbers of mice used within experiments were as follows: WT, n = 28; Nestin-Cre⁺ IFN-γR2^flox/flox, n = 20. (D) Survival of the different strains. Results are representative of 2 independent experiments with 4 or 5 mice per group.