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. 2016 Jul 4;14(10):830–841. doi: 10.1038/cmi.2016.31

Figure 1.

Figure 1

BRD7−/− mice are more susceptible to surface inflammation. (a) Genotype identification of BRD7 knockout mice. The three types of representative tissues (intestine, spleen and lung) were obtained from BRD7+/+ and BRD7−/− mice, and the expression of BRD7 was detected by western blotting using an antibody specific for BRD7. (b) The number of animals with external inflammation (the upper), abdominal abscess (the middle) and splenomegaly (the lower) in BRD7−/− and BRD7+/+ mice. (c) Representative images of the external inflammation, abdominal abscess and splenomegaly inflammation sites in BRD7−/− mice (left). Representative H&E-stained sections from BRD7−/− inflammation mice (right; all pictures at a × 100 magnification except for the BRD7−/− splenomegaly magnification of × 200). Arrows indicate megakaryocytes and coenocytes cells. BRD7, bromodomain-containing protein 7; H&E, hematoxylin and eosin. The data are expressed as the mean values±s.d. **P<0.01, ***P<0.001.