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. 2017 Oct 12;8:1288. doi: 10.3389/fimmu.2017.01288

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Copyright © 2017 Pagliari, Munari, Toffoletto, Lonardi, Chemello, Codolo, Millino, Della Bella, Pacchioni, Vermi, Fassan, de Bernard and Cagnin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Integration of microRNAs (miRNAs) and mRNA targets. The network describes the interactions between miRNAs downregulated both after 24 and 72 h of Helicobacter pylori (Hp) infection and the predicted targets. The higher the node size is, the higher the number of edges connected with it is. Color scale mirrors the expression of miRNAs and genes in Hp-infected vs non-infected macrophages (Ctrl). Triangles represent miRNAs, whereas round squares refer to mRNAs. Dashes edges interconnect miRNAs with their targets, whereas filled edges describe functional relationships between different mRNAs. Arrows indicate genes, and miRNAs for whom the expression was confirmed in human derived macrophages by qRT-PCR.