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. 2017 Sep 26;9:309. doi: 10.3389/fnagi.2017.00309

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Copyright © 2017 Guan, Liu, Jiang, Tao, Zhang, Niu, Zhu, Wang, Cheng, Kochan, Brodaty, Sachdev and Wen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The selection frequencies of the stable features for naMCI vs. CN classification. The baseline, wave-2 or longitudinal frequency are the selection frequencies of the feature measured at baseline, wave-2 or longitudinally, respectively. The selection frequency (between 0 and 3,000) of each feature is indicative of the discriminative power for classification. Volume of left temporal pole is a more important biomarker in former time point. When measured longitudinally, volume of right rostral anterior cingulate and thickness of right middle frontal are not selected in the first 10 feature list. The right amygdala volume is stable over time. lTP, left temporal pole volume; rA, right amygdala volume; rRAC, right rostral anterior cingulate volume; rRMF, right rostral middle frontal thickness.