Table 3.

Selected features for the classification of aMCI vs. CN.

Task	Baseline feature	Frequency	pa	Wave-2 feature	Frequency	pa	Longitudinal feature	Frequency	pa
aMCI vs. CN	Right frontal pole thickness	2,658	0.001	Right frontal pole thickness	2,786	<0.001	Right frontal pole thickness	2,715	<0.001
	Right thalamus volume	2,136	0.006	Right hippocampus volume	2,105	<0.001	Right thalamus volume	2,470	0.001
	Left superior temporal thickness	1,620	0.001	Right thalamus volume	1,775	0.001	Right hippocampus volume	2,071	0.001
	Right hippocampus volume	1,344	0.005	Left superior temporal thickness	1,144	0.005	Left superior temporal thickness	1,212	0.002
	Right g-SIc	1,265	0.003	Left sucal width of superior frontal	1,062	0.002	Right sucal width of superior temporalb*	1,036	0.027
	Right transverse temporal thicknessc	755	0.013	Right sucal width of superior frontalc	963	0.001	Right pericalcarine thickness	876	0.004
	Right pericalcarine thickness	736	0.005	Right amygdala volumec	963	0.073	Left precentral thicknessb*	869	0.035
	Right rostral anterior cingulate volumec	693	0.128	Right pericalcarine thickness	958	0.006	Left inferior temporal thickness*	827	0.019
	Right paracentral thicknessc	637	0.022	Right accumbens volumec	660	0.011	Right paracentral thicknessb*	819	0.012
	Left posterior cingulate volumec	545	0.134	Left medial orbitofrontal thicknessc	633	0.045	Right sulcal width of superior frontal	722	0.002

A feature measured at baseline, wave-2 or longitudinally is defined as baseline feature, wave-2 feature or longitudinal feature, respectively. The first 10 most frequently selected features and their selection frequencies are listed. The maximum possible selection frequency of each feature is 3000. The features with selection frequencies above 1500 are in bold. wave-2, 2-year follow-up; MCI, mild cognitive impairment; CN, cognitively normal; aMCI, amnestic MCI.

^aResults for comparisons of positive subjects and negative subjects using t-tests.

^bChanges measurements, the rest longitudinal features are means measurements.

^cFeatures that were selected at a single time point (either at baseline or wave-2).

^*Features that were selected only in longitudinal case.