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. 2017 Oct 4;8:759. doi: 10.3389/fphys.2017.00759

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Copyright © 2017 Whittaker, Ni, Benson, Hancox and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Single cell action potentials and current traces. (Ai) Endocardial action potential (AP) at 1 Hz under WT (silver, dashed line), SQT1 (red, solid line), SQT1 + 5μM disopyramide (DISO) (blue, solid line), and SQT1 + 2μM quinidine (QUIN) (green, solid line) conditions. Corresponding current traces are shown for I_Kr (Aii), I_Na (Aiii), and I_CaL (Aiv). The degree of fractional block of I_Kr and I_Na is shown in (Av,Avi), respectively. The concentration dependence of the single cell AP duration at 90% repolarization (APD₉₀) and maximum upstroke velocity (MUV) is shown in (Bi,Bii), respectively.