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. 2017 Oct 4;8:759. doi: 10.3389/fphys.2017.00759

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Copyright © 2017 Whittaker, Ni, Benson, Hancox and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative snapshots of re-entry under SQT1 and pharmacological modulation conditions. The evolution of scroll waves following initiation of re-entry for time t = 100, 200, 500, 1,000, 3,000, and 5,000 ms is shown for SQT1 (Ai), SQT1 + 2 μM disopyramide (DISO) (Bi), and SQT1 + 2 μM quinidine (QUIN) (Ci) conditions from an epicardial aspect. In each case, localized AP excitations (Aii,Bii,Cii), corresponding fractional block of I_Na (red) and I_Kr (blue) (Aiii,Biii,Ciii), and pseudo ECG traces (Aiv,Biv,Civ) are shown.