FIGURE 5.

Dynamic changes of canonical pathways of nervous and cardiovascular system post sciatic nerve transection. (A) The changes of major canonical pathways of nervous system signaling at different time points post nerve transection. (B) The changes of major canonical pathways of cardiovascular signaling at different time points post nerve transection. Agrin interactions at neuromuscular junction (NMJ) and Ephrin B signaling were successively activated (z-score ≥ 2), while synaptic long term depression and CDK5 signaling were successively inhibited (z-score ≤ –2) (A). Inhibition of angiogenesis by TSP1 was successively activated (z-score ≥ 2). Endothelin-1 signaling was activated (z-score ≥ 2) at 1, 4, and 7 days, but inhibited at 14 days (B). Each bar represented a pathway with significance of enrichment determined using –log (p) value. Orange, a positive z-score ≥ 2, represented the activation of canonical pathway. Blue, a negative z-score ≤ –2, represented the inhibition of canonical pathway.