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Number of edges obtained after applying DTNI to gene expression data from primary human hepatocytes exposed to chemicals with distinct toxicity.
| Pathway | Carcinogenic | DILI | Non-carcinogenic/non-DILI |
|---|---|---|---|
| ER | 22 | 57 | 0 |
| NF-κB | 20 | 39 | 39 |
| NRF2 | 59 | 29 | 0 |
| TP53 | 8 | 94 | 0 |
Carcinogenic: azathioprine and cyclophosphamide, DILI: diclofenac, propylthiouracil, and nitrofurantoin, Non-carcinogenic/non-DILI: diazepam, omeprazole, and aspirin.
