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Number of distinct biological processes affected by groups of chemicals related to investigated pathways – results from overrepresentation analysis using differentially expressed genes.
| Pathway | Carcinogenic | DILI | Non-carcinogenic/non-DILI |
|---|---|---|---|
| ER | 1 | 1 | 0 |
| NF-κB | 0 | 2 | 2 |
| NRF2 | 3 | 3 | 3 |
| TP53 | 4 | 4 | 3 |
Carcinogenic: azathioprine and cyclophosphamide, DILI: diclofenac, propylthiouracil, and nitrofurantoin, Non-carcinogenic/non-DILI: diazepam, omeprazole, and aspirin.
