Table 2.
Univariate analysis of rate of breast and nodal downstaging for various pathologic features
| Breast | Axilla | |||
|---|---|---|---|---|
| Tumor Pathologic Characteristic | Downstaged to BCS (n=239) |
p-value | Nodal pCR (n=301) |
p-value |
| Histology* | <0.0001 | 0.086 | ||
| Ductal | 48% (88/183) | 16% (40/245) | ||
| Lobular | 16% (9/56) | 7% (4/55) | ||
| Differentiation* | 0.010 | 0.002 | ||
| Well/Moderate | 33% (34/103) | 8% (10/130) | ||
| Poor | 50% (61/122) | 21% (32/156) | ||
| Nuclear grade* | 0.058 | 0.0001 | ||
| 1/2 | 37% (42/113) | 5% (7/136) | ||
| 3 | 51% (36/70) | 26% (24/92) | ||
| PR status** | 0.030 | 0.024 | ||
| PR+ | 36% (61/169) | 11% (25/219) | ||
| PR− | 52% (34/66) | 22% (17/78) | ||
*
unknowns excluded
**
excludes 4ER−PR+ patients
BCS, breast-conserving surgery; pCR, pathologic complete response; PR, progesterone receptor