Table 3.
Multivariate analysis of rate of breast and axillary downstaging for various pathologic features
| Breast *n=225; 95 events |
Axilla *n=286; 42 events |
|||
|---|---|---|---|---|
| Tumor Pathologic Characteristic | Downstaging to BCS OR |
p-value | Nodal pCR OR |
p-value |
| Histology (lobular vs ductal) | 0.223 | 0.0007 | 0.493 | 0.276 |
| Differentiation (poor vs well/moderate) | 1.30 | 0.397 | 2.667 | 0.014 |
| PR status (− vs +) | 1.59 | 0.139 | 1.89 | 0.077 |
*
unknowns excluded
OR, odds ratio; BCS, breast-conserving surgery; pCR, pathologic complete response; PR, progesterone receptor