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. Author manuscript; available in PMC: 2017 Oct 20.
Published in final edited form as: Thromb Haemost. 2010 Sep 30;105(1):21–30. doi: 10.1160/TH10-07-0446

Figure 4. Resistant to degradation by C-terminal truncation without CUB-domains.

Figure 4

(A) Two truncation mutants lacking the catalytic (DTSTC) or CUB domains (MDTST7) were expressed in CHO cells and recombinant proteins purified from the conditioned medium and stored for two weeks. DTSTC underwent proteolysis, whereas MDTST7 was resistant. (B) Degradation of WT rADAMTS-13 was inhibited by a protease inhibitor cocktail, but not by EDTA. The figure is a representative of three separate experiments.