Table 1. Ratios of ADAMTS-13 secretion and mutants to medium/extracelluar matrix.
Mutation | Densitometry | Medium/ECM ratio | |
---|---|---|---|
medium | ECM | ||
WT | 1.00 | 1.00 | 1.00 |
C1192S | 0.21 ± 0.01 | 1.52 ± 0.10 | 0.14 |
C1213S | 0.25 ± 0.04 | 1.60 ± 0.09 | 0.16 |
C1236S | 0.23 ± 0.03 | 1.53 ± 0.09 | 0.15 |
C1254S | 0.28 ± 0.02 | 1.50 ± 0.08 | 0.19 |
C1275S | 0.89 ± 0.01 | 1.24 ± 0.06 | 0.72 |