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. Author manuscript; available in PMC: 2017 Oct 20.
Published in final edited form as: J Immunol. 2017 Mar 15;198(8):3296–3306. doi: 10.4049/jimmunol.1602059

FIGURE 2.

FIGURE 2

Biological effects of p38 inhibitors. (A and B) Effect of 10 μM SB203580 (SB), or indicated concentration of UM60 or 101 on HMVECL permeability (A) and capacity for IL-8–directed neutrophil TEM (B). Cells were pretreated with DMSO or compounds for 1 h, then incubated with 10 ng/ml TNF-α for 6 h at 39.5°C prior to permeability assay (A) or at 39.5°C without additional stimulus for 6 h prior to TEM assay (B). Mean ± SE. *p < 0.0001 versus DMSO, †p < 0.0001 versus SB, ‡p < 0.005 versus 37°C. (C and D) Male CD1 mice were pretreated with 1 mg SB or 0.1–1 mg UM101 prior to i.t. instillation of 50 μg LPS and hyperthermia exposure. *p < 0.05 versus DMSO.