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(A) Simulation of hENM model using stochastic gradient descent (blue) and full covariance matrix (green) to bias the two shown CVs as well as their variance, with otherwise identical algorithmic parameters, (B) The full covariance method is compared to the Levenberg-Marquardt (LM) algorithm with γ = 0.1, γ = 0.01, and the adaptive algorithm with starting γ = 0.1.
