Table 4.

Causes of bleeding in patients with cirrhosis-thrombocytopathy [2, 7]

Sequestration of platelets in the spleen

Reduced production of thrombopoietin

Co-morbidities (viral infections, alcoholism, malnutrition)

Myelosuppression (viral infections, alcoholism, folate deficiency, drugs)

In HCV-infected immunological thrombocytopenia

Disordered platelet function

Disordered production

Acquired storage disorder

Disorders of secretion

Changed NO concentration (and altered activity)

Changes in the concentration of arachidonic acid in the platelet wall (less TXA2)

Effect of circulating paraproteins