(A) Convexity is defined using the concept of a convex hull. In mathematical terms, the convex hull of a set of points is the minimum region that fully contains all line segments between any two arbitrary points in the set. From a conceptual standpoint, the convex hull of a polygon would be represented by the shape of a rubber band stretched around the outside of that polygon. In this sense, we can imagine the dashed line surrounding the two pores in the panel to be this rubber band. Specifically, for this study, we defined convexity as the ratio of the area of the pore to the area of the convex hull of the pore. (B) Aspect ratio was defined as the ratio of the major axis length to the minor axis length.