Table II.

Univariate analysis of RFS times for the 65 patients with hepatocellular carcinoma studied.

Variable	n	P-value
Sex		0.33
Male	51
Female	14
Age, years		0.302
<60	41
≥60	24
Tumor size, cm		0.0067b
<5	28
≥5	37
AFP, ng/ml		0.1673
<20	26
≥20	39
Histological grade		0.5412
Well	2
Moderately/poorly	56
Clinical stage		0.7505
I and II	47
III and IV	18
Tumor number		0.3714
Solitary	54
Multiple	11
Alcohol consumption		0.7186
Yes	30
No	35
Smoking status		0.4280
Yes	23
No	42
HBV		0.4855
Yes	39
No	26
PVTT		0.0407a
Yes	33
No	32
Microvascular invasion		0.0261a
Yes	47
No	18
Liver cirrhosis		0.5881
Absence	35
Presence	25
LOC728290 expression		0.047a
Low	33
High	32

Decreased RFS times were identified to be significantly associated with microvascular invasion, PVTT and low expression of LOC728290. However, RFS times were not significantly associated with sex, age, tumor size, liver cirrhosis, histological grade, drinking state, smoking state, HBV and clinical stage.

^aP<0.05

^bP<0.01. RFS, recurrence-free survival; AFP, α-fetoprotein; HBV, hepatitis B virus; PVTT, portal vein tumor thrombosis.