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Metformin activates AMPK and inhibits the mammalian target of rapamycin signaling pathway in the Ishikawa and HEC-1-A cell lines. Western blot analysis of p-AMPK, AMPK, p-p70S6K and p70S6K protein levels following treatment with the indicated concentrations of metformin for 24 h. Results are representative of three independent experiments. AMPK, 5′ AMP-activated protein kinase; p70S6K, ribosomal protein S6 kinase β-1; p, phosphorylated; Con, control; Met, metformin.
