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. 2017 Nov;45(11):1197–1214. doi: 10.1124/dmd.117.077024

Fig. 1.

Fig. 1.

(A) Diagram illustrating the experimental design and dosing regimen of mice. Briefly, 9-week-old C57BL/6J CV mice were treated with vehicle (corn oil, 10 ml/kg, oral gavage), BDE-47 (10 or 100 μmol/kg, oral gavage), or BDE-99 (10 or 100 μmol/kg, oral gavage) once daily for 4 days (n = 5 per group). Tissues were collected 24 hours after the final dose. Age-matched GF mice were treated with vehicle (corn oil, 10 ml/kg, oral gavage), BDE-47 (100 μmol/kg, oral gavage), or BDE-99 (100 μmol/kg, oral gavage) following the same procedure (n = 3 or 4 per group). (B) RT-qPCR of mRNAs of the prototypical aryl hydrocarbon receptor–target gene Cyp1a2, the prototypical CAR-target gene Cyp2b10, and the prototypical PXR-target gene Cyp3a11 in liver of CV mice treated with corn oil, BDE-47 (10 or 100 μmol/kg), or BDE-99 (10 or 100 μmol/kg). Data are expressed as percentage of the housekeeping gene β-actin (n = 5 per group). Asterisks (*) indicate statistically significant differences between corn oil–treated and PBDE-treated groups in liver (P < 0.05).