TABLE 1.

DPGs differentially regulated by the lack of gut microbiome and by PBDEs in livers of CV and GF mice treated with corn oil, BDE-47 (100 μmol/kg), or BDE-99 (100 μmol/kg). CV, conventional mice; GF, germ-free mice; CO, corn oil.

Category	Treatment	Phase I	Phase II	Transporter
A. Genes differentially regulated by gut microbiome (CVCO vs. GFCO)	Corn oil	Cyp1a2, Cyp2b9, Cyp2b13, Cyp2c (2c40, 2c50, 2c54, 2c67, 2c68, 2c69, 2c70), Cyp2e1, Cyp2g1, Cyp2j9, Cyp3a (3a11, 3a16, 3a41a, 3a41b, 3a44, 3a59)	Sult1a1, Sult1b1, Papss2, Gstm2, Gstm6	Abcb1a, Abcc10
B. Genes differentially regulated by PBDEs only in CV mice (gut microbiome–dependent effect)	BDE-47	Cyp1a2, Cyp2c39, Cyp2d13, Cyp2g1, Cyp2j9	Ugt2b1, Ugt2b5, Sult5a1, Gstm2, Gstp1, Gstp2	Abcb1b, Abcc3, Abcc4, Abcc10
	BDE-99	Cyp2a22, Cyp2c39, Cyp2g1, Cyp2r1, Cyp3a13	Ugt2b37, Sult2a7
C. Genes differentially regulated by PBDEs preferably in GF mice (augmentation effect due to the lack of gut microbiome)	BDE-47	Cyp2a4, Cyp2a22, Cyp2b9, Cyp2b13, Cyp2c37, Cyp2c54, Cyp3a11, Cyp3a16, Cyp3a41a, Cyp3a41b, Cyp3a44	Sult2a2, Gsta2, Gstm3, Gstt3	Slco1a4
	BDE-99	Cyp1a1, Cyp1a2, Cyp2a4, Cyp2a5, Cyp2b10, Cyp2c (2c37, 2c40, 2c50, 2c54, 2c55, 2c69), Cyp2d (2d11, 2d12, 2d13, 2d34, 2d40), Cyp2j9, Cyp3a (3a16, 3a25, 3a41a, 3a41b, 3a44, 3a59)	Ugt2b1, Ugt2b35, Ugt2b38, Ugdh, Ugp2, Sult1d1, Sult1e1, Papss2, Gsta1, Gsta2, Gstm2, Gstm3, Gstt3, Gclc	Slco1a4, Slco1b2, Slco2a1, Abcc2, Abcc10