Figure 1.

Differences in morphology and growth between HCC1806 and HCC1806-TxR cells. (A) The establishment of a drug-resistant phenotype in HCC1806 cells was associated with alterations to cell morphology. HCC1806-TxR cells (left) exhibited an increasingly oval shape, an enlarged size and a increased nucleus/cytoplasm ratio compared with the parental HCC1806 cells (right). (B) Growth kinetics of HCC1806 and HCC1806-TxR cells treated with a range of paclitaxel concentrations. The normal growth of the TxR subline was similar to the HCC1806 parental line; however, when treated with paclitaxel, the relative growth was greater in the TxR cells. TxR, taxol resistant.