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. 2017 Aug 14;14(4):4467–4476. doi: 10.3892/ol.2017.6752

Figure 2.

Figure 2.

E6 expression is enhanced with cervical cancer tumour staging. (A) Low intensity E6 expression was observed in T1 tumours, whereas (B) T2 and (C) T3 staged tumours demonstrated increased expression of E6. (D) Box plot summary of the IRS for each tumour stage (P=0.017, FIGO 1 vs. 3). E6 expression was positively correlated with FIGO classification, with (E) FIGO 1 classified tissue demonstrating low expression of E6 while (F) FIGO 2 and (G) FIGO 3 classified tissue demonstrated increased expression levels, and (H) FIGO 4 tissue further increased expression levels. (I) Box plot summary of the IRS for each FIGO stage (P<0.001, FIGO 1 vs. 4). (J) Squamous epithelial tissue demonstrated lower levels of E6 staining than (K) adenocarcinoma tissue. (L) Box plot summary of the IRS for each histological subtype. Scale bar, 200 µm. FIGO, International Federation of Gynecology and Obstetrics; IRS, immunoreactive score; E6Cyt, E6 cytoplasmic; pT, pathological tumour stage.